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Target
Beta-glucuronidase
Ligand
BDBM163636
Substrate
n/a
Meas. Tech.
ChEMBL_1983584 (CHEMBL4616990)
IC50
164±n/a nM
Citation
 Awolade, P; Cele, N; Kerru, N; Gummidi, L; Oluwakemi, E; Singh, P Therapeutic significance of ?-glucuronidase activity and its inhibitors: A review. Eur J Med Chem 187:0 (2020) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
3.2.1.31 | BGLR_MOUSE | Beta-glucuronidase | Gus | Gus-s | Gusb
Type:
PROTEIN
Mol. Mass.:
74196.88
Organism:
Mus musculus
Description:
ChEMBL_118935
Residue:
648
Sequence:
MSLKWSACWVALGQLLCSCALALKGGMLFPKESPSRELKALDGLWHFRADLSNNRLQGFEQQWYRQPLRESGPVLDMPVPSSFNDITQEAALRDFIGWVWYEREAILPRRWTQDTDMRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADISKLVQSGPLTTCRITIAINNTLTPHTLPPGTIVYKTDTSMYPKGYFVQDTSFDFFNYAGLHRSVVLYTTPTTYIDDITVITNVEQDIGLVTYWISVQGSEHFQLEVQLLDEGGKVVAHGTGNQGQLQVPSANLWWPYLMHEHPAYMYSLEVKVTTTESVTDYYTLPIGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGKGFDWPLLVKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNESLRHHLEVMEELVRRDKNHPAVVMWSVANEPSSALKPAAYYFKTLITHTKALDLTRPVTFVSNAKYDADLGAPYVDVICVNSYFSWYHDYGHLEVIQPQLNSQFENWYKTHQKPIIQSEYGADAIPGIHEDPPRMFSEEYQKAVLENYHSVLDQKRKEYVVGELIWNFADFMTNQSPLRVIGNKKGIFTRQRQPKTSAFILRERYWRIANETGGHGSGPRTQCFGSRPFTF
  
Inhibitor
Name:
BDBM163636
Synonyms:
3[(6,8Dimethyl2oxo1,2dihydroquinolin3 yl)methyl]1(4ethoxyphenyl)3(2hydroxyethyl)thiourea (Inh 1) | US9334288, 1
Type:
Small organic molecule
Emp. Form.:
C23H27N3O3S
Mol. Mass.:
425.544
SMILES:
CCOc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: