Reaction Details Report a problem with these data
Target
DNA (cytosine-5)-methyltransferase 3A
Ligand
BDBM50544058
Substrate
n/a
Meas. Tech.
ChEMBL_1991444 (CHEMBL4625179)
Kd
900±n/a nM
Citation
 Sergeev, A; Vorobyov, A; Yakubovskaya, M; Kirsanova, O; Gromova, E Novel anticancer drug curaxin CBL0137 impairs DNA methylation by eukaryotic DNA methyltransferase Dnmt3a. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
DNA (cytosine-5)-methyltransferase 3A
Synonyms:
2.1.1.- | 2.1.1.37 | Cysteine methyltransferase DNMT3A | DNA (cytosine-5)-methyltransferase 3A | DNA MTase MmuIIIA | DNA methyltransferase MmuIIIA | DNM3A_MOUSE | Dnmt3a
Type:
PROTEIN
Mol. Mass.:
101671.89
Organism:
Mus musculus
Description:
ChEMBL_108012
Residue:
908
Sequence:
MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESSDTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTETPPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVEEASPPAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
  
Inhibitor
Name:
BDBM50544058
Synonyms:
CHEMBL4640631
Type:
Small organic molecule
Emp. Form.:
C21H24N2O2
Mol. Mass.:
336.4275
SMILES:
CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O
Structure:
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