Reaction Details Report a problem with these data
Target
Protein phosphatase 1 regulatory subunit 15A
Ligand
BDBM50545524
Substrate
n/a
Meas. Tech.
ChEMBL_1995424 (CHEMBL4629319)
IC50
977±n/a nM
Citation
 Cornella-Taracido, I; Garcia-Echeverria, C Monovalent protein-degraders - Insights and future perspectives. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Protein phosphatase 1 regulatory subunit 15A
Synonyms:
GADD34 | Growth arrest and DNA damage-inducible protein GADD34 | Myeloid differentiation primary response protein MyD116 homolog | PPP1R15A | PR15A_HUMAN | Protein phosphatase 1 regulatory subunit 15A
Type:
PROTEIN
Mol. Mass.:
73417.94
Organism:
Homo sapiens
Description:
ChEMBL_119898
Residue:
674
Sequence:
MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG
  
Inhibitor
Name:
BDBM50545524
Synonyms:
CHEMBL2369159
Type:
Small organic molecule
Emp. Form.:
C8H8Cl2N4
Mol. Mass.:
231.082
SMILES:
NC(=N)N\N=C\c1cccc(Cl)c1Cl
Structure:
Search PDB for entries with ligand similarity: