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Target
Protein phosphatase 1 regulatory subunit 15B
Ligand
BDBM50545524
Substrate
n/a
Meas. Tech.
ChEMBL_1995425 (CHEMBL4629320)
IC50
33±n/a nM
Citation
 Cornella-Taracido, I; Garcia-Echeverria, C Monovalent protein-degraders - Insights and future perspectives. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Protein phosphatase 1 regulatory subunit 15B
Synonyms:
PPP1R15B | PR15B_HUMAN | Protein phosphatase 1 regulatory subunit 15B
Type:
PROTEIN
Mol. Mass.:
79104.24
Organism:
Homo sapiens
Description:
ChEMBL_119923
Residue:
713
Sequence:
MEPGTGGSRKRLGPRAGFRFWPPFFPRRSQAGSSKFPTPLGPENSGNPTLLSSAQPETRVSYWTKLLSQLLAPLPGLLQKVLIWSQLFGGMFPTRWLDFAGVYSALRALKGREKPAAPTAQKSLSSLQLDSSDPSVTSPLDWLEEGIHWQYSPPDLKLELKAKGSALDPAAQAFLLEQQLWGVELLPSSLQSRLYSNRELGSSPSGPLNIQRIDNFSVVSYLLNPSYLDCFPRLEVSYQNSDGNSEVVGFQTLTPESSCLREDHCHPQPLSAELIPASWQGCPPLSTEGLPEIHHLRMKRLEFLQQANKGQDLPTPDQDNGYHSLEEEHSLLRMDPKHCRDNPTQFVPAAGDIPGNTQESTEEKIELLTTEVPLALEEESPSEGCPSSEIPMEKEPGEGRISVVDYSYLEGDLPISARPACSNKLIDYILGGASSDLETSSDPEGEDWDEEAEDDGFDSDSSLSDSDLEQDPEGLHLWNSFCSVDPYNPQNFTATIQTAARIVPEEPSDSEKDLSGKSDLENSSQSGSLPETPEHSSGEEDDWESSADEAESLKLWNSFCNSDDPYNPLNFKAPFQTSGENEKGCRDSKTPSESIVAISECHTLLSCKVQLLGSQESECPDSVQRDVLSGGRHTHVKRKKVTFLEEVTEYYISGDEDRKGPWEEFARDGCRFQKRIQETEDAIGYCLTFEHRERMFNRLQGTCFKGLNVLKQC
  
Inhibitor
Name:
BDBM50545524
Synonyms:
CHEMBL2369159
Type:
Small organic molecule
Emp. Form.:
C8H8Cl2N4
Mol. Mass.:
231.082
SMILES:
NC(=N)N\N=C\c1cccc(Cl)c1Cl
Structure:
Search PDB for entries with ligand similarity: