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Target
Mu-type opioid receptor
Ligand
BDBM50551313
Substrate
n/a
Meas. Tech.
ChEMBL_2031140 (CHEMBL4685298)
Ki
0.013600±n/a nM
Citation
 Sz?cs, E; Marton, J; Szabó, Z; Hosztafi, S; Kékesi, G; Tuboly, G; Bánki, L; Horváth, G; Szabó, PT; Tömböly, C; Varga, ZK; Benyhe, S; Ötvös, F Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives. Eur J Med Chem 191:0 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50551313
Synonyms:
CHEMBL4745764
Type:
Small organic molecule
Emp. Form.:
C24H31NO4
Mol. Mass.:
397.5072
SMILES:
[H][C@]12Oc3c4c(C[C@@]5([H])N(C)CC[C@]14C51C[C@]([H])([C@@](C)(O)CCC)[C@]2(O)C=C1)ccc3O |r,c:30,TLB:3:4:12.11.9:14,28:5:12.11.9:14,4:13:16.15:26.27,12:13:16.15:26.27,THB:18:16:13.1:26.27|
Structure:
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