Reaction Details Report a problem with these data
Target
G-protein coupled receptor 183
Ligand
BDBM50558428
Substrate
n/a
Meas. Tech.
ChEMBL_2063683 (CHEMBL4718936)
EC50
0.102000±n/a nM
Citation
 Deng, X; Sun, S; Wu, J; Kuei, C; Joseph, V; Liu, C; Mani, NS Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability. Bioorg Med Chem Lett 26:4888-4891 (2016) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 183
Synonyms:
EBI2 | GP183_HUMAN | GPR183
Type:
PROTEIN
Mol. Mass.:
41245.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108311
Residue:
361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
  
Inhibitor
Name:
BDBM50558428
Synonyms:
CHEMBL4779254
Type:
Small organic molecule
Emp. Form.:
C28H45F3O3
Mol. Mass.:
486.6503
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@@]3([H])[C@]([H])(CC[C@]12C)[C@@]1(C)CC[C@H](O)CC1=C[C@]3(O)C(F)(F)F)[C@H](C)CCCC(C)(C)O |r,c:24|
Structure:
Search PDB for entries with ligand similarity: