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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM50559399
Substrate
n/a
Meas. Tech.
ChEMBL_2069196 (CHEMBL4724449)
IC50
7.2±n/a nM
Citation
 Olson, KL; Holt, MC; Ciske, FL; Kramer, JB; Heiple, PE; Collins, ML; Johnson, CM; Ho, CS; Morano, MI; Barrett, SD Novel amide and imidazole compounds as potent hematopoietic prostaglandin D Bioorg Med Chem Lett 34:0 (2021) [PubMed]  Article 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM50559399
Synonyms:
CHEMBL4753053
Type:
Small organic molecule
Emp. Form.:
C23H21N5O3
Mol. Mass.:
415.4445
SMILES:
CC(C)(O)c1nc(no1)-c1cccc(CNC(=O)c2cnc(nc2)-c2ccccc2)c1
Structure:
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