Reaction Details Report a problem with these data
Target
Kinesin-like protein KIF18A
Ligand
BDBM50561742
Substrate
n/a
Meas. Tech.
ChEMBL_2075814 (CHEMBL4731348)
IC50
14±n/a nM
Citation
 Sabnis, RW Novel KIF18A Inhibitors for Treating Cancer. ACS Med Chem Lett 11:2079-2080 (2020) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF18A
Synonyms:
KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A
Type:
PROTEIN
Mol. Mass.:
102320.22
Organism:
Homo sapiens
Description:
ChEMBL_119153
Residue:
898
Sequence:
MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNSSLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
  
Inhibitor
Name:
BDBM50561742
Synonyms:
CHEMBL4777623
Type:
Small organic molecule
Emp. Form.:
C24H29F2N5O3S
Mol. Mass.:
505.581
SMILES:
Cc1cc(NC(=O)c2ccc(NS(C)(=O)=O)cc2N2CCC3(CC3)CC2)nc(c1)N1CC(F)(F)C1
Structure:
Search PDB for entries with ligand similarity: