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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50159379
Substrate
n/a
Meas. Tech.
ChEMBL_302457 (CHEMBL875207)
Ki
500±n/a nM
Citation
 Reck, F; Zhou, F; Girardot, M; Kern, G; Eyermann, CJ; Hales, NJ; Ramsay, RR; Gravestock, MB Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A. J Med Chem 48:499-506 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50159379
Synonyms:
(R)-3-[4-(1,1-Dioxo-1,2,3,6-tetrahydro-1lambda*6*-thiopyran-4-yl)-3-fluoro-phenyl]-5-(4-fluoro-[1,2,3]triazol-1-ylmethyl)-oxazolidin-2-one | CHEMBL177061
Type:
Small organic molecule
Emp. Form.:
C17H16F2N4O4S
Mol. Mass.:
410.395
SMILES:
Fc1cn(C[C@H]2CN(C(=O)O2)c2ccc(C3=CCS(=O)(=O)CC3)c(F)c2)nn1 |t:16|
Structure:
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