Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50167288
Substrate
n/a
Meas. Tech.
ChEMBL_302276 (CHEMBL830295)
Ki
0.072000±n/a nM
Citation
 Barrett, DG; Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Willard, DH; Wright, LL Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 15:3039-43 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_RAT | Ctsk
Type:
PROTEIN
Mol. Mass.:
36798.82
Organism:
Rattus norvegicus
Description:
ChEMBL_633322
Residue:
329
Sequence:
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
  
Inhibitor
Name:
BDBM50167288
Synonyms:
(1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarboxylate | CHEMBL191558
Type:
Small organic molecule
Emp. Form.:
C13H17N3O2
Mol. Mass.:
247.293
SMILES:
CC[C@@H](Cc1ccccc1)OC(=O)NN(C)C#N
Structure:
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