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Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50174821
Substrate
n/a
Meas. Tech.
ChEMBL_326855 (CHEMBL860452)
Ki
>3000±n/a nM
Citation
 Palani, A; Shapiro, S; McBriar, MD; Clader, JW; Greenlee, WJ; O'Neill, K; Hawes, B Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett 15:5234-6 (2005) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50174821
Synonyms:
1-(3'-cyano-biphenyl-4-ylmethyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-(3-pyrrolidin-1-yl-propyl)-urea | CHEMBL197279
Type:
Small organic molecule
Emp. Form.:
C29H28F4N4O
Mol. Mass.:
524.5524
SMILES:
Fc1ccc(NC(=O)N(CCCN2CCCC2)Cc2ccc(cc2)-c2cccc(c2)C#N)cc1C(F)(F)F
Structure:
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