Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50176455
Substrate
n/a
Meas. Tech.
ChEMBL_332996 (CHEMBL853593)
Ki
64.9±n/a nM
Citation
 Geneste, H; Backfisch, G; Braje, W; Delzer, J; Haupt, A; Hutchins, CW; King, LL; Lubisch, W; Steiner, G; Teschendorf, HJ; Unger, L; Wernet, W Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com. Bioorg Med Chem Lett 16:658-62 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50176455
Synonyms:
(R)-1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)-2-methylbutyl)-3,4-dihydroquinolin-2(1H)-one | CHEMBL426111
Type:
Small organic molecule
Emp. Form.:
C27H36F3N5O
Mol. Mass.:
503.6028
SMILES:
C[C@H](CCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F)CN1C(=O)CCc2ccccc12
Structure:
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