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Target
D(3) dopamine receptor
Ligand
BDBM50177368
Substrate
n/a
Meas. Tech.
ChEMBL_329734 (CHEMBL864615)
Ki
51±n/a nM
Citation
 Chen, J; Ding, K; Levant, B; Wang, S Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorg Med Chem Lett 16:443-6 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50177368
Synonyms:
CHEMBL373052 | N-(trans-4-(2-(8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethyl)cyclohexyl)quinoline-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C31H38N4O2
Mol. Mass.:
498.659
SMILES:
COc1ccc2N3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4cnc5ccccc5c4)CC3CCc2c1 |wU:15.18,wD:12.11,(15.94,-16.85,;17.27,-16.08,;18.61,-16.86,;18.6,-18.4,;19.93,-19.17,;21.28,-18.4,;22.62,-19.18,;22.63,-20.73,;23.98,-21.5,;25.33,-20.71,;26.66,-21.47,;27.99,-20.7,;29.33,-21.46,;29.33,-23,;30.66,-23.76,;31.99,-22.99,;31.99,-21.45,;30.65,-20.68,;33.33,-23.76,;33.33,-25.3,;34.67,-26.06,;32,-26.07,;32.01,-27.6,;30.68,-28.38,;29.34,-27.61,;28.02,-28.37,;26.69,-27.61,;26.69,-26.07,;28.02,-25.31,;29.34,-26.07,;30.67,-25.3,;25.32,-19.15,;23.97,-18.39,;23.96,-16.84,;22.61,-16.06,;21.27,-16.85,;19.93,-16.09,)|
Structure:
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