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TargetCathepsin K
LigandBDBM50410591
Substrate/Competitorn/a
Meas. Tech.ChEMBL_325792
Ki 0.94±n/a nM
Citation Palmer, JTBryant, CWang, DXDavis, DESetti, ELRydzewski, RMVenkatraman, STian, ZQBurrill, LCMendonca, RVSpringman, EMcCarter, JChung, TCheung, HJanc, JWMcGrath, MSomoza, JREnriquez, PYu, ZWStrickley, RMLiu, LVenuti, MCPercival, MDFalgueyret, JPPrasit, POballa, RRiendeau, DYoung, RNWesolowski, GRodan, SBJohnson, CKimmel, DBRodan, G Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem48:7520-34 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:n/a
Type:Enzyme
Mol. Mass.:36879.51
Organism:Oryctolagus cuniculus (rabbit)
Description:n/a
Residue:329
Sequence:
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50410591
NameBDBM50410591
Synonyms:CHEMBL200506
TypeSmall organic molecule
Emp. Form.C25H32N6O2S
Mol. Mass.480.626
SMILESCN1CCN(Cc2nc(cs2)-c2ccc(cc2)C(=O)NC2(CCCCC2)C(=O)NCC#N)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a