Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50178628
Substrate
n/a
Meas. Tech.
ChEMBL_325303 (CHEMBL859710)
Ki
10.6±n/a nM
Citation
 Leopoldo, M; Lacivita, E; Colabufo, NA; Contino, M; Berardi, F; Perrone, R First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure. J Med Chem 48:7919-22 (2005) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50178628
Synonyms:
CHEMBL168948 | cis-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-phenylcyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C27H35Cl2N3O
Mol. Mass.:
488.492
SMILES:
Clc1cccc(N2CCN(CCCCNC(=O)[C@H]3CC[C@H](CC3)c3ccccc3)CC2)c1Cl |wD:17.16,20.23,(11.27,-12.19,;9.95,-11.41,;9.97,-9.86,;8.64,-9.08,;7.3,-9.84,;7.29,-11.37,;5.95,-12.12,;5.92,-13.66,;4.59,-14.41,;3.27,-13.63,;1.93,-14.39,;1.92,-15.93,;.58,-16.7,;-.75,-15.93,;-.75,-14.39,;-2.09,-13.62,;-2.09,-12.08,;-3.42,-14.39,;-4.76,-13.61,;-6.09,-14.38,;-6.09,-15.92,;-4.76,-16.69,;-3.42,-15.93,;-7.43,-16.68,;-8.76,-15.91,;-10.1,-16.67,;-10.1,-18.21,;-8.76,-18.99,;-7.43,-18.22,;3.27,-12.09,;4.62,-11.34,;8.61,-12.16,;8.59,-13.7,)|
Structure:
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