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Target
Genome polyprotein
Ligand
BDBM50181687
Substrate
n/a
Meas. Tech.
ChEMBL_331787 (CHEMBL864671)
IC50
>30000±n/a nM
Citation
 Powers, JP; Piper, DE; Li, Y; Mayorga, V; Anzola, J; Chen, JM; Jaen, JC; Lee, G; Liu, J; Peterson, MG; Tonn, GR; Ye, Q; Walker, NP; Wang, Z SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase. J Med Chem 49:1034-46 (2006) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Bovine viral diarrhoea virus polyprotein | POLG_BVDVC
Type:
PROTEIN
Mol. Mass.:
439189.54
Organism:
Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal diseasevirus)
Description:
ChEMBL_331787
Residue:
3907
Sequence:
MELITNELLYKTYKQKPAGVEEPVYDQAGNPLFGERGVIHPQSTLKLPHKRGEREVPTNLASLPKRGDCRSGNSKGPVSGIYLKPGPLFYQDYKGPVYHRAPLEFFEEASMCETTKRIGRVTGSDSRLYHIYVCIDGCIIVKSATKDRQKVLKWVHNKLNCPLWVSSCSDTKDEGVVRKKQQKPDRLEKGRMKITPKESEKDSKTKPPDATIVVDGVKYQVKKKGKVKSKNTQDGLYHNKNKPQESRKKLEKALLAWAIIALVFFQVTMGENITQWNLQDNGTEGIQRAMFQRGVNRSLHGIWPEKICTGVPSHLATDTELKAIHGMMDASEKTNYTCCRLQRHEWNKHGWCNWYNIEPWILLMNKTQANLTEGQPLRECAVTCRYDRDSDLNVVTQARDSPTPLTGCKKGKNFSFAGILVQGPCNFEIAVSDVLFKEHDCTSVIQDTAHYLVDGMTNSLESARQGTAKLTTWLGRQLGILGKKLENKSKTWFGAYAASPYCEVERKLGYIWYTKNCTPACLPRNTKIIGPGRFDTNAEDGKILHEMGGHLSEVLLLSVVVLSDFAPETASVIYLILHFSIPQGHTDIQDCDKNQLNLTVELTTAEVIPGSVWNLGKYVCVRPDWWPYETATVLVIEEVGQVIKVVLRALKDLTRIWTAATTTAFLVCLVKVVRGQVLQGILWLMLITGAQGYPDCKPGFSYAIAKNDEIGPLGATGLTTQWYEYSDGMRLQDSVVEVWCKNGEIKYLIRCGREARYLAVLHTRALPTSVVFEKIFDGKEQEDIVEMDDNFEFGLCPCDARPLIRGKFNTTLLNGPAFQMVCPIGWTGTVSCTLANKDTLATIVVRTYKRVRPFPYRQDCVTQKTIGEDLYDCALGGNWTCVPGDALRYVAGPVESCEWCGYKFLKSEGLPHFPIGKCRLKNESGYRQVDETSCNRNGVAIVPSGTVKCKIGDTVVQVIAMDDKLGPMPCKPHEIISSEGPVEKTACTFNYTRTLKNKYFEPRDNYFQQYMLKGEYQYWFDLEITDHHRDYFAESLLVIVVALLGGRYVLWLLVTYMILSEQMASGVQYGAGEIVMMGNLLTHDSVEVVTYFLLLYLLLREENTKKWVILIYHIIVMHPLKSVTVILLMVGGMAKAEPGAQGYLEQVDLSFTMITIIVIGLVIARRDPTVVPLVTIVAALKITGLGFGPGVDAAMAVLTLTLLMTSYVTDYFRYKRWIQCILSLVAGVFLIRTLKHLGELKTPELTIPNWRPLTFILLYLTSATVVTRWKIDIAGIFLQGAPILLMIATLWADFLTLVLILPTYELAKLYYLKNVKTDVEKSWGVPYPDPQTLGGLDYRTIDSVYDVDESGEGVYLFPSRQKKNKNISILLPLIRATLISCISSKWQMVYMAYLTLDFMYYMHRKVIEEISGSTNVMSRVIAALIELNWSMEEEESKGLKKFFILSGRLRNLIIKHKVRNQTVASWYGEEEVYGMPKVVTIIRACTLNKNKHCIICTVCEARKWKGGNCPKCGRHGKPIICGMTLADFEERHYKRIFIREGNFEGPFRQEYNGFVQYTARGQLFLRNLPILATKVKMIMVGNLGEEIGDLEHLGWILRGPAVCKKITEHEKCHVNILDKLTAFFGVMPRGTTPRAPVRFPTALLKVRRGLETGWAYTHQGGISSVDHVTAGKDLLVCDSMGRTRVVCQSNNKLTDETEYGVKTDSGCPDGARCYVLNPEAVNISGSKGAVVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNEESKPTKLMSGIQTVSKNTADLTEMVKKITSMNRGDFRQITLATGAGKTTELPKAVIEEIGRHKRVLVLIPLRAAAESVYQYMRLKHPSISFNLRIGDMKEGDMATGITYASYGYFCQMPQPKLRAAMIEYSYIFLDEYHCATPEQLAVIGKIHRFSESIRVVAMTATPAGSVTTTGQKHPIEEFIAPEVMKGEDLGSQFLDIAGLKIPVEEMKGNMLVFVPTRNMAVEVAKKLKAKGYNSGYYYSGEDPANLRVVTSQSPYVVVATNAIESGVTLPDLDTVVDTGLKCEKRVRVSSKIPFIVTGLKRMAVTVGEQAQRRGRVGRVKPGRYYRSQETATGSKDYHYDLLQAQRYGIEDGINVTKSFREMNYDWSLYEEDSLLITQLEILNNLLISEDLPAAVKNIMARTDHPEPIQLAYNSYEVQVPVLFPKIRNGEVTDTYENYSFLNARKLGEDVPVYVYATEDEDLAVDLLGLDWPDPGNQQVVETGKALKQVVGLSSAENALLIALFGYVGYQALSKRHVPMITDIYTIEDQRLEDTTHLQYAPNAIRTEGKETELKELAVGDLDKIMGSISDYASEGLNFVRSQAEKMRSAPAFKENVEAAKGYVQKFIDSLIENKETIIRYGLWGTHTALYKSIAARLGHETAFATLVIKWLAFGGESVSDHMRQAAVDLVVYYVINKPSFPGDSETQQEGRRFVASLFISALATYTYKTWNYNNLSKVVEPALAYLPYATNALKMFTPTRLESVVILSTTIYKTYLSIRKGKSDGLLGTGISAAMEILSQNPVSVGISVMLGVGAIAAHNAIESSEQKRTLLMKVFVKNFLDQAATDELVKENPEKIIMALFEAVQTIGNPLRLIYHLYGVYYKGWEAKELSERTAGRNLFTLIMFEAFELLGMDSEGKIRNLSGNYVLDLIYSLHKQINRGLKKIVLGWAPAPFSCDWTPSDERIRLPTNNYLRVETKCPCGYEMKALRNVGGSLTKVEEKGPFLCRNRLGRGPVNYRVTKYYDDNLKEIKPVAKLEGFVDHYYKGVTARIDYGRGKMLLATDKWEVEHGVVTRLAKRYTGVGFKGAYLGDEPNHRDLVERDCATITKNTVQFLKMKKGCAFTYDLTLSNLTRLIELVHKNNLEEKDIPAATVTTWLAYTFVNEDIGTIKPVLGERVVTDPVVDVNLQPEVQVDTSEVGITLVGRAALMTTGTTPVVEKTEPNADGGPSSIKIGLDEGRYPGPGLQDRTLTDEIHSRDERPFVLVLGSKNSMSNRAKTARNINLYKGNNPREIRDLMAQGRMLVVALKDFNPELSELVDFKGTFLDREALEALSLGRPKSKQVTTATVRELLEQEVQVEIPSWFGAGDPVFLEVTLKGDRYHLVGDVDRVKDQAKELGATDQTRIVKEVGARTYTMKLSSWFLQATNKQMSLTPLFEELLLRCPPKIKSNKGHMASAYQLAQGNWEPLDCGVHLGTIPARRVKIHPYEAYLKLKDLLEEEEKKPKCRDTVIREHNKWILKKVRHQGNLNTKKILNPGKLSEQLDREGHKRNIYNNQIGTIMTEAGSRLEKLPVVRAQTDTKSFHEAIRDKIDKNENQQSPGLHDKLLEIFHTIAQPSLRHTYSDVTWEQLEAGVNRKGAAGFLEKKNVGEVLDSEKHLVEQLIRDLKTGRKIRYYETAIPKNEKRDVSDDWQSGDLVDEKKPRVIQYPEAKTRLAITKVMYNWVKQQPVVIPGYEGKTPLFNIFNKVRKEWDLFNEPVAVSFDTKAWDTQVTSRDLRLIGEIQKYYYRKEWHKFIDTITDHMVEVPVITADGEVYIRNGQRGSGQPDTSAGNSMLNVLTMMYAFCESTGVPYKSFNRVARIHVCGDDGFLITEKGLGLKFANNGMQILHEAGKPQKITEGERMKVAYRFEDIEFCSHTPVPVRWSDNTSSYMAGRDTAVILSKMATRLDSSGERGTIAYEKAVAFSFLLMYSWNPLVRRICLLVLSQQPETTPSTQTTYYYKGDPIGAYKDVIGKNLCELKRTGFEKLANLNLSLSTLGIWSKHTSKRIIQDCVTIGKEEGNWLVNADRLISSKTGHLYIPDKGYTLQGKHYEQLQLQARTSPVTGVGTERYKLGPIVNLLLRRLRVLLMAAVGASS
  
Inhibitor
Name:
BDBM50181687
Synonyms:
5-(4-chlorobenzylidene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine | CHEMBL377720
Type:
Small organic molecule
Emp. Form.:
C16H11ClN2O3S3
Mol. Mass.:
410.918
SMILES:
Clc1ccc(C=C2SC(=S)N(NS(=O)(=O)c3ccccc3)C2=O)cc1 |w:5.4|
Structure:
Search PDB for entries with ligand similarity: