Reaction Details Report a problem with these data
Target
Deoxyuridine triphosphatase, putative
Ligand
BDBM50186267
Substrate
n/a
Meas. Tech.
ChEMBL_366108 (CHEMBL864792)
Ki
18400±n/a nM
Citation
 Mc Carthy, OK; Schipani, A; Buendía, AM; Ruiz-Perez, LM; Kaiser, M; Brun, R; Pacanowska, DG; Gilbert, IH Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase. Bioorg Med Chem Lett 16:3809-12 (2006) [PubMed]  Article 
Target
Name:
Deoxyuridine triphosphatase, putative
Synonyms:
Deoxyuridine triphosphatase
Type:
PROTEIN
Mol. Mass.:
38920.01
Organism:
Trypanosoma cruzi
Description:
ChEMBL_366108
Residue:
340
Sequence:
MEAQLRATSFLWHHPLQVSGCLNFLFIYFSSFLFRVLFLFYSTSLLCLFLSVLAVLEMNRVQSSFRVPARVLNSLVHLQDGLNTFMDPDWRQIRHVDDWALAITMESAELIDSYPWKWWKNVKAQADMHNVRIEIADILHFSLSGEMQKRTQDGKGAGDVALKSLKEMGFFCRPPAHAKSTEASDHRTNGGDDDGDDELLELIFFPLTEVASAVATFRNIIQLASIYRFDLITKGLLLAAQDLDFNLVGYYVAKYTLNQIRQLKGYKEGAYVKVREGVEDNELLHECVQSVSVEDVLNEGTYLKTWEKIACSVFDAFGMPEEERRHAYEWLKSAALEGKR
  
Inhibitor
Name:
BDBM50186267
Synonyms:
2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP
Type:
Small organic molecule
Emp. Form.:
C9H13N2O8P
Mol. Mass.:
308.1819
SMILES:
O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: