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Target
Histamine H3 receptor
Ligand
BDBM50193175
Substrate
n/a
Meas. Tech.
ChEMBL_422153 (CHEMBL713681)
Ki
11.2±n/a nM
Citation
 Lau, JF; Jeppesen, CB; Rimvall, K; Hohlweg, R Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides. Bioorg Med Chem Lett 16:5303-8 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50193175
Synonyms:
(S)-3-(4-chlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)prop-2-en-1-one | CHEMBL218991
Type:
Small organic molecule
Emp. Form.:
C18H23ClN2O
Mol. Mass.:
318.841
SMILES:
Clc1ccc(\C=C\C(=O)N2CCC[C@H]2CN2CCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: