Reaction Details Report a problem with these data
Target
Urotensin-2 receptor
Ligand
BDBM50224718
Substrate
n/a
Meas. Tech.
ChEMBL_450869 (CHEMBL899955)
Ki
30±n/a nM
Citation
Luci, DK; Ghosh, S; Smith, CE; Qi, J; Wang, Y; Haertlein, B; Parry, TJ; Li, J; Almond, HR; Minor, LK; Damiano, BP; Kinney, WA; Maryanoff, BE; Lawson, EC Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment. Bioorg Med Chem Lett 17:6489-92 (2007) [PubMed] Article
More Info.:
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42159.71
Organism:
Homo sapiens (Human)
Description:
Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:
389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
Inhibitor
Name:
BDBM50224718
Synonyms:
CHEMBL239250 | N-((1-(benzylsulfonyl)piperidin-4-yl)methyl)-5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)piperidin-4-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C35H41ClN4O5S
Mol. Mass.:
665.242
SMILES:
Clc1ccc(C2CCN(CCN3C(=O)COc4ccccc34)CC2)c(c1)C(=O)NCC1CCN(CC1)S(=O)(=O)Cc1ccccc1