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Target
Neutrophil elastase
Ligand
BDBM50280683
Substrate
n/a
Meas. Tech.
ChEBML_96645
KON
930 M-1s-1
Citation
 Alpegiani, M; Bissolino, P; Borghi, D; Corigli, R; Nero, SD; Perrone, E; Razzano, G; Rizzo, V Cephem sulfones as inactivators of human leukocyte elastase. II. Keto-enol tautomerish in cephem-4-ketones. Bioorg Med Chem Lett 2:1127-1132 (1992)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50280683
Synonyms:
(6R,7S)-2-Benzoyl-4-(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]triazin-3-ylsulfanyl)-7-methoxy-3-methyl-5,5-dioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-en-8-one | CHEMBL14659
Type:
Small organic molecule
Emp. Form.:
C19H18N4O7S2
Mol. Mass.:
478.499
SMILES:
CO[C@@H]1[C@@H]2N(C1=O)C(C(=O)c1ccccc1)=C(C)C(Sc1nc(=O)c(=O)[nH]n1C)S2(=O)=O |t:17|
Structure:
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