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Target
Prothrombin
Ligand
BDBM50288405
Substrate
n/a
Meas. Tech.
ChEBML_208357
Ki
0.160000±n/a nM
Citation
 Galemmo, RA; Fevig, JM; Carini, DJ; Cacciola, J; Wells, BL; Hillyer, GL; Jr., JB; Rossi, KA; Stouten, PF; Alexander, RS; Hilmer, R; Bostrom, L; Abelman, MM; Lee, SL; Weber, PC; Kettner, CA; Knabb, RM; Wexler, RR (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors Bioorg Med Chem Lett 6:2913-2918 (1996)    Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50288405
Synonyms:
CHEMBL95940 | N-[(1-Dihydroxyboranyl-4-guanidino-butylcarbamoyl)-methyl]-N-methyl-3-phenyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C17H28BN5O4
Mol. Mass.:
377.246
SMILES:
CN(CC(=O)N[C@@H](CCCNC(N)=N)B(O)O)C(=O)CCc1ccccc1
Structure:
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