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Target
D(1A) dopamine receptor
Ligand
BDBM50292559
Substrate
n/a
Meas. Tech.
ChEMBL_483725 (CHEMBL997480)
IC50
>30000±n/a nM
Citation
 Cortes, D; Figadere, B; Saez, J; Protais, P Displacement Activity of Bisbenzylisoquinoline Alkaloids at Striatal 3H-SCH 23390 and 3H-Raclopride Binding Sites J Nat Prod 55:1281-1286 (1992) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50292559
Synonyms:
(S)-secoobaberine hydrochloride | CHEMBL451463
Type:
Small organic molecule
Emp. Form.:
C38H40N2O8
Mol. Mass.:
652.7328
SMILES:
COc1ccc(C=O)cc1Oc1ccc(C[C@@H]2N(C)CCc3cc(OC)c(OC)c(Oc4cc5C(=O)N(C)CCc5cc4OC)c23)cc1 |r|
Structure:
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