Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50292556
Substrate
n/a
Meas. Tech.
ChEMBL_483726 (CHEMBL997481)
IC50
2760±n/a nM
Citation
 Cortes, D; Figadere, B; Saez, J; Protais, P Displacement Activity of Bisbenzylisoquinoline Alkaloids at Striatal 3H-SCH 23390 and 3H-Raclopride Binding Sites J Nat Prod 55:1281-1286 (1992) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50292556
Synonyms:
(S,S)-oxandrine hydrochloride | CHEMBL445011
Type:
Small organic molecule
Emp. Form.:
C37H38N2O7
Mol. Mass.:
622.7068
SMILES:
COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(c4)-c4cc(ccc4O)C(=O)[C@H]4N(C)CCc5cc(OC)c(Oc(c1O)c23)cc45 |r|
Structure:
Search PDB for entries with ligand similarity: