Reaction Details Report a problem with these data
Target
Cytochrome P450 4X1
Ligand
BDBM50293851
Substrate
n/a
Meas. Tech.
ChEMBL_572390 (CHEMBL1035291)
IC50
24000±n/a nM
Citation
 Liu, W; Liu, K; Wood, HB; McCann, ME; Doebber, TW; Chang, CH; Akiyama, TE; Einstein, M; Berger, JP; Meinke, PT Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia. J Med Chem 52:4443-53 (2009) [PubMed]  Article 
Target
Name:
Cytochrome P450 4X1
Synonyms:
CP4X1_HUMAN | CYP4X1 | CYPIVX1 | Cytochrome P450 4X1 | Cytochrome P450, family 4, subfamily X, polypeptide 1, isoform CRA_c
Type:
PROTEIN
Mol. Mass.:
58891.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102388
Residue:
509
Sequence:
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLSEC
  
Inhibitor
Name:
BDBM50293851
Synonyms:
(2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}butanoic Acid | CHEMBL552240
Type:
Small organic molecule
Emp. Form.:
C28H23ClF3NO5
Mol. Mass.:
545.934
SMILES:
CC[C@@H](Oc1cccc(Cn2c(C)c(C(=O)c3ccc(Cl)cc3)c3ccc(OC(F)(F)F)cc23)c1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: