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TargetUTS2R
LigandBDBM50302227
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596665
IC50 150±n/a nM
Citation Lawson, ECLuci, DKGhosh, SKinney, WAReynolds, CHQi, JSmith, CEWang, YMinor, LKHaertlein, BJParry, TJDamiano, BPMaryanoff, BE Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem52:7432-45 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UTS2R
Name:UTS2R
Synonyms:G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | SENR | UR-II-R | Urotensin-II
Type:Enzyme Catalytic Domain
Mol. Mass.:42725.34
Organism:RAT
Description:Urotensin-II UTS2R RAT::P49684
Residue:386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA
MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD
VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL
TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL
SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY
LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG
RSLSSSSQQATETLMLSPVPRNGALL
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  Blast E-value cutoff:
BDBM50302227
NameBDBM50302227
Synonyms:4-(4-benzylpiperazin-1-yl)-2-(3,4-dimethoxybenzyl)isoindoline-1,3-dione | CHEMBL566187
TypeSmall organic molecule
Emp. Form.C28H29N3O4
Mol. Mass.471.5476
SMILESCOc1ccc(CN2C(=O)c3cccc(N4CCN(Cc5ccccc5)CC4)c3C2=O)cc1OC
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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