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Target
Sialidase-2
Ligand
BDBM7462
Substrate
n/a
Meas. Tech.
ChEMBL_617801 (CHEMBL1100507)
IC50
230000±n/a nM
Citation
 Arioka, S; Sakagami, M; Uematsu, R; Yamaguchi, H; Togame, H; Takemoto, H; Hinou, H; Nishimura, S Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase. Bioorg Med Chem 18:1633-40 (2010) [PubMed]  Article 
Target
Name:
Sialidase-2
Synonyms:
Cytosolic sialidase | N-acetyl-alpha-neuraminidase 2 | NEU2 | NEUR2_HUMAN | Sialidase 2 | Sialidase-2
Type:
PROTEIN
Mol. Mass.:
42256.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960638
Residue:
380
Sequence:
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
  
Inhibitor
Name:
BDBM7462
Synonyms:
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one | CHEMBL150 | Kaempferol (18) | Kaempferol (Kmp) | cid_5280863 | kaempferol
Type:
Small organic molecule
Emp. Form.:
C15H10O6
Mol. Mass.:
286.2363
SMILES:
Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Structure:
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