Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50315816
Substrate
n/a
Meas. Tech.
ChEMBL_626103 (CHEMBL1111629)
EC50
3.6±n/a nM
Citation
 Hamada, M; Nakamura, M; Kiuchi, M; Marukawa, K; Tomatsu, A; Shimano, K; Sato, N; Sugahara, K; Asayama, M; Takagi, K; Adachi, K Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate. J Med Chem 53:3154-68 (2010) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50315816
Synonyms:
2-Amino-4-(2'-fluoro-4'-phenylthiobiphenyl-4-yl)-2-(phosphoryloxymethyl)butanol | CHEMBL1092286
Type:
Small organic molecule
Emp. Form.:
C23H25FNO5PS
Mol. Mass.:
477.485
SMILES:
NC(CO)(CCc1ccc(cc1)-c1ccc(Sc2ccccc2)cc1F)COP(O)(O)=O
Structure:
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