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Target
D(1A) dopamine receptor
Ligand
BDBM50316967
Substrate
n/a
Meas. Tech.
ChEMBL_630119 (CHEMBL1113710)
Ki
1630±n/a nM
Citation
 Fiorino, F; Severino, B; De Angelis, F; Perissutti, E; Magli, E; Frecentese, F; Esposito, A; Massarelli, P; Nencini, C; Santagada, V; Caliendo, G New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation. Bioorg Med Chem Lett 20:2978-82 (2010) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50316967
Synonyms:
CHEMBL1086958 | N-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-N'-cyanoisonicotinamidine
Type:
Small organic molecule
Emp. Form.:
C20H23ClN6
Mol. Mass.:
382.89
SMILES:
Clc1cccc(c1)N1CCN(CCCN=C(NC#N)c2ccncc2)CC1 |w:14.14|
Structure:
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