Reaction Details Report a problem with these data
Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM50325328
Substrate
n/a
Meas. Tech.
ChEMBL_652120 (CHEMBL1228229)
IC50
10±n/a nM
Citation
 Owen, CP; Shahid, I; Lee, WY; Ahmed, S Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes. Bioorg Med Chem Lett 20:5345-8 (2010) [PubMed]  Article 
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
Enzyme
Mol. Mass.:
57255.68
Organism:
Rattus norvegicus (Rat)
Description:
P11715
Residue:
507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
  
Inhibitor
Name:
BDBM50325328
Synonyms:
4-((1H-imidazol-1-yl)methyl)phenyl biphenyl-4-sulfonate | CHEMBL1222987
Type:
Small organic molecule
Emp. Form.:
C22H18N2O3S
Mol. Mass.:
390.455
SMILES:
O=S(=O)(Oc1ccc(Cn2ccnc2)cc1)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: