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Target
Translation factor GUF1, mitochondrial
Ligand
BDBM50326696
Substrate
n/a
Meas. Tech.
ChEMBL_661423 (CHEMBL1252883)
IC50
300000±n/a nM
Citation
 Butcher, RA; Bhullar, BS; Perlstein, EO; Marsischky, G; LaBaer, J; Schreiber, SL Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem Biol 2:103-9 (2006) [PubMed]  Article 
Target
Name:
Translation factor GUF1, mitochondrial
Synonyms:
EF-4 | Elongation factor 4 homolog | GTPase GUF1 | GUF1 | GUF1_YEAST | Ribosomal back-translocase
Type:
PROTEIN
Mol. Mass.:
73210.19
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_661423
Residue:
645
Sequence:
MLKFRIRPVRHIRCYKRHAYFLRYNHTTTPAQKLQAQIEQIPLENYRNFSIVAHVDHGKSTLSDRLLEITHVIDPNARNKQVLDKLEVERERGITIKAQTCSMFYKDKRTGKNYLLHLIDTPGHVDFRGEVSRSYASCGGAILLVDASQGIQAQTVANFYLAFSLGLKLIPVINKIDLNFTDVKQVKDQIVNNFELPEEDIIGVSAKTGLNVEELLLPAIIDRIPPPTGRPDKPFRALLVDSWYDAYLGAVLLVNIVDGSVRKNDKVICAQTKEKYEVKDIGIMYPDRTSTGTLKTGQVGYLVLGMKDSKEAKIGDTIMHLSKVNETEVLPGFEEQKPMVFVGAFPADGIEFKAMDDDMSRLVLNDRSVTLERETSNALGQGWRLGFLGSLHASVFRERLEKEYGSKLIITQPTVPYLVEFTDGKKKLITNPDEFPDGATKRVNVAAFHEPFIEAVMTLPQEYLGSVIRLCDSNRGEQIDITYLNTNGQVMLKYYLPLSHLVDDFFGKLKSVSRGFASLDYEDAGYRISDVVKLQLLVNGNAIDALSRVLHKSEVERVGREWVKKFKEYVKSQLYEVVIQARANNKIIARETIKARRKDVLQKLHASDVSRRKKLLAKQKEGKKHMKTVGNIQINQEAYQAFLRR
  
Inhibitor
Name:
BDBM50326696
Synonyms:
6-(phenylamino)quinoline-5,8-dione | 6-Phenylamino-quinoline-5,8-dione | CHEMBL312487
Type:
Small organic molecule
Emp. Form.:
C15H10N2O2
Mol. Mass.:
250.2521
SMILES:
O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12 |t:2|
Structure:
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