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TargetAdhesin protein fimH
LigandBDBM50347452
Substrate/Competitorn/a
Meas. Tech.ChEMBL_755504
IC50 16±n/a nM
Citation Klein, TAbgottspon, DWittwer, MRabbani, SHerold, JJiang, XKleeb, SLüthi, CScharenberg, MBezençon, JGubler, EPang, LSmiesko, MCutting, BSchwardt, OErnst, B FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem53:8627-41 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adhesin protein fimH
Name:Adhesin protein fimH
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:31474.61
Organism:Escherichia coli (strain K12)
Description:ChEMBL_1298296
Residue:300
Sequence:
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLS
TQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRT
DKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTG
GCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQ
GVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50347452
NameBDBM50347452
Synonyms:CHEMBL1802190
TypeSmall organic molecule
Emp. Form.C20H20Cl2O8
Mol. Mass.459.274
SMILESCOC(=O)c1ccc(cc1)-c1cc(Cl)c(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)c(Cl)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a