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Target
D(2) dopamine receptor
Ligand
BDBM50290214
Substrate
n/a
Meas. Tech.
ChEBML_58455
Ki
3±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50290214
Synonyms:
CHEMBL312430 | Furan-2-carboxylic acid (4-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C23H29Cl2N3O2
Mol. Mass.:
450.401
SMILES:
Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3ccco3)CC2)c1Cl |wU:12.11,wD:15.18,(20.54,-4.81,;19.81,-6.17,;20.61,-7.5,;19.86,-8.85,;18.32,-8.87,;17.53,-7.56,;15.99,-7.59,;15.27,-8.92,;13.73,-8.96,;12.93,-7.65,;11.39,-7.68,;10.62,-9.01,;9.08,-9.03,;8.31,-10.36,;6.77,-10.37,;6,-9.04,;6.75,-7.71,;8.29,-7.7,;4.46,-9.04,;3.69,-10.37,;2.15,-10.38,;4.46,-11.7,;5.96,-11.37,;6.74,-12.67,;5.72,-13.84,;4.3,-13.23,;13.67,-6.31,;15.21,-6.28,;18.28,-6.21,;17.48,-4.9,)|
Structure:
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