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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50009835
Substrate
n/a
Meas. Tech.
ChEMBL_32101 (CHEMBL644302)
IC50
110±n/a nM
Citation
 Mylari, BL; Beyer, TA; Siegel, TW A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem 34:1011-8 (1991) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50009835
Synonyms:
4-Hydroxy-5-oxo-1-pyridin-4-ylmethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester | CHEMBL266773
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4
Mol. Mass.:
262.2613
SMILES:
CCOC(=O)C1CN(Cc2ccncc2)C(=O)C1=O
Structure:
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