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Reaction Details
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TargetAldehyde reductase
LigandBDBM50049730
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31308
IC50 1500±n/a nM
Citation Mylari, BLBeyer, TASiegel, TW A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners. J Med Chem34:1011-8 (1991) [PubMed]  Article
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Aldehyde reductase
Name:Aldehyde reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:36541.05
Organism:Sus scrofa
Description:ChEMBL_615076
Residue:325
Sequence:
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIYGNELEIGEAL
TETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEK
YNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIV
PMLTVDGKRVPRDAGHPLYPFNDPY
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  Blast E-value cutoff:
BDBM50049730
NameBDBM50049730
Synonyms:2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | CHEMBL56337 | Epalrestat | {5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid
TypeSmall organic molecule
Emp. Form.C15H13NO3S2
Mol. Mass.319.399
SMILESC\C(\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1
Structure
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n/a