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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50008061
Substrate
n/a
Meas. Tech.
ChEBML_61994
IC50
9030±n/a nM
Citation
 Abraham, P; Pitner, JB; Lewin, AH; Boja, JW; Kuhar, MJ; Carroll, FI N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor. J Med Chem 35:141-4 (1992) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50008061
Synonyms:
3,5-Difluoro-benzoic acid 6-methyl-6-aza-bicyclo[3.2.1]oct-3-yl ester | CHEMBL32987
Type:
Small organic molecule
Emp. Form.:
C15H17F2NO2
Mol. Mass.:
281.2978
SMILES:
CN1CC2CC1CC(C2)OC(=O)c1cc(F)cc(F)c1 |TLB:9:7:1.2:4,THB:0:1:4:6.7.8|
Structure:
Search PDB for entries with ligand similarity: