Reaction Details Report a problem with these data
Target
Cathepsin D
Ligand
BDBM50008157
Substrate
n/a
Meas. Tech.
ChEBML_44987
IC50
259±n/a nM
Citation
Doherty, AM; Sircar, I; Kornberg, BE; Quin, J; Winters, RT; Kaltenbronn, JS; Taylor, MD; Batley, BL; Rapundalo, SR; Ryan, MJ Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors. J Med Chem 35:2-14 (1992) [PubMed] Article
More Info.:
Target
Name:
Cathepsin D
Synonyms:
CATD_BOVIN | CTSD
Type:
PROTEIN
Mol. Mass.:
42158.92
Organism:
Bos taurus
Description:
ChEMBL_1458606
Residue:
387
Sequence:
VIRIPLHKFTSIRRTMSEAAGVLIAKGPISKYATGEPAVRQGPIPELLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSANLWVPSIHCKLLDIACWTHRKYNSDKSSTYVKNGTTFDIHYGSGSLSGYLSQDTVSVPCNPSSSSPGGVTVQRQTFGEAIKQPGVVFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDKNVFSFFLNRDPKAQPGGELMLGGTDSKYYRGSLMFHNVTRQAYWQIHMDQLDVGSSLTVCKGGCEAIVDTGTSLIVGPVEEVRELQKAIGAVPLIQGEYMIPCEKVSSLPEVTVKLGGKDYALSPEDYALKVSQAETTVCLSGFMGMDIPPPGGPLWILGDVFIGRYYTVFDRDQNRVGLAEAARL
Inhibitor
Name:
BDBM50008157
Synonyms:
4-(1-{1-[1-Cyclohexylmethyl-3,3-difluoro-2-hydroxy-3-(2-methyl-butylcarbamoyl)-propylcarbamoyl]-but-3-enylcarbamoyl}-2-phenyl-ethylsulfamoyl)-piperazine-1-carboxylic acid tert-butyl ester | CHEMBL32239
Type:
Small organic molecule
Emp. Form.:
C39H62F2N6O8S
Mol. Mass.:
813.007
SMILES:
CC[C@H](C)CNC(=O)C(F)(F)C(O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC=C)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCN(CC1)C(=O)OC(C)(C)C