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Target
Platelet-activating factor receptor
Ligand
BDBM50003507
Substrate
n/a
Meas. Tech.
ChEBML_154975
IC50
17000±n/a nM
Citation
 Carceller, E; Almansa, C; Merlos, M; Giral, M; Bartrolí, J; García-Rafanell, J; Forn, J (Pyridylcyanomethyl)piperazines as orally active PAF antagonists. J Med Chem 35:4118-34 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50003507
Synonyms:
(4-Pyridin-3-ylmethyl-piperazin-1-yl)-(3,4,5-trimethoxy-phenyl)-methanone; dihydrochloride; hydrate | CHEMBL3215547
Type:
Small organic molecule
Emp. Form.:
C20H27Cl2N3O4
Mol. Mass.:
444.352
SMILES:
Cl.Cl.COc1cc(cc(OC)c1OC)C(=O)N1CCN(Cc2cccnc2)CC1
Structure:
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