Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50004107
Substrate
n/a
Meas. Tech.
ChEMBL_226550 (CHEMBL846627)
IC50
1100±n/a nM
Citation
 Kimes, AS; Wilson, AA; Scheffel, U; Campbell, BG; London, ED Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites. J Med Chem 35:4683-9 (1993) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50004107
Synonyms:
1-(1-Thiophen-2-yl-cyclohexyl)-piperidine | CHEMBL279676 | Tenocyclidine
Type:
Small organic molecule
Emp. Form.:
C15H23NS
Mol. Mass.:
249.415
SMILES:
C1CCN(CC1)C1(CCCCC1)c1cccs1
Structure:
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