Target
Beta-1 adrenergic receptor
Ligand
BDBM50000498
Substrate
n/a
Meas. Tech.
ChEBML_37542
Ki
>100000±n/a nM
Citation
 Macchia, BBalsamo, ABreschi, MCLapucci, ALucacchini, AMacchia, FManera, CMartinelli, AMartini, CMartinotti, E Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors. J Med Chem 35:1009-18 (1992) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2
Type:
Protein
Mol. Mass.:
50486.84
Organism:
Rattus norvegicus (Rat)
Description:
P18090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM50000498
Synonyms:
2-Amino-1,2,3,4-tetrahydro-naphthalene-1,6,7-triol | CHEMBL7185
Type:
Small organic molecule
Emp. Form.:
C10H13NO3
Mol. Mass.:
195.2151
SMILES:
N[C@@H]1CCc2cc(O)c(O)cc2[C@H]1O
Structure:
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