Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor A
Ligand
BDBM50003154
Substrate
n/a
Meas. Tech.
ChEBML_36154
Ki
0.610000±n/a nM
Citation
 Winn, M; De, B; Zydowsky, TM; Altenbach, RJ; Basha, FZ; Boyd, SA; Brune, ME; Buckner, SA; Crowell, D; Drizin, I 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. J Med Chem 36:2676-88 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50003154
Synonyms:
2-{Propyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-nicotinic acid | 2-{Propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-nicotinic acid | A-81988 | CHEMBL416477
Type:
Small organic molecule
Emp. Form.:
C23H22N6O2
Mol. Mass.:
414.4598
SMILES:
CCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1ncccc1C(O)=O
Structure:
Search PDB for entries with ligand similarity: