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Target
Thermolysin
Ligand
BDBM50035239
Substrate
n/a
Meas. Tech.
ChEMBL_210393 (CHEMBL814123)
IC50
9±n/a nM
Citation
 Bihovsky, R; Levinson, BL; Loewi, RC; Erhardt, PW; Polokoff, MA Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle. J Med Chem 38:2119-29 (1995) [PubMed]  Article 
Target
Name:
Thermolysin
Synonyms:
THER_BACTH | npr
Type:
PROTEIN
Mol. Mass.:
60097.54
Organism:
Bacillus thermoproteolyticus
Description:
ChEMBL_1468794
Residue:
548
Sequence:
MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEELVYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDGTLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVYVNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK
  
Inhibitor
Name:
BDBM50035239
Synonyms:
CHEMBL63317 | N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy-2-isopropyl-malonamide
Type:
Small organic molecule
Emp. Form.:
C17H22N4O4
Mol. Mass.:
346.381
SMILES:
CC(C)C(C(=O)NO)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O
Structure:
Search PDB for entries with ligand similarity: