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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50039834
Substrate
n/a
Meas. Tech.
ChEMBL_138834 (CHEMBL753022)
EC50
12000±n/a nM
Citation
 Messer, WS; Abuh, YF; Liu, Y; Periyasamy, S; Ngur, DO; Edgar, MA; El-Assadi, AA; Sbeih, S; Dunbar, PG; Roknich, S; Rho, T; Fang, Z; Ojo, B; Zhang, H; Huzl, JJ; Nagy, PI Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists. J Med Chem 40:1230-46 (1997) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_MOUSE | Chrm-3 | Chrm3 | Mm3 mAChR | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M3
Type:
PROTEIN
Mol. Mass.:
66232.94
Organism:
Mus musculus
Description:
ChEMBL_138834
Residue:
589
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50039834
Synonyms:
6-Amino-2,3,4,5-tetrahydro-pyridine-3-carboxylic acid prop-2-ynyl ester; hydrochloride | CHEMBL557795
Type:
Small organic molecule
Emp. Form.:
C9H12N2O2
Mol. Mass.:
180.2038
SMILES:
NC1=NCC(CC1)C(=O)OCC#C |t:1|
Structure:
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