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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50065259
Substrate
n/a
Meas. Tech.
ChEMBL_33966 (CHEMBL649591)
Ki
4700±n/a nM
Citation
 Asano, N; Nishida, M; Kato, A; Kizu, H; Matsui, K; Shimada, Y; Itoh, T; Baba, M; Watson, AA; Nash, RJ; Lilley, PM; Watkin, DJ; Fleet, GW Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases. J Med Chem 41:2565-71 (1998) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50065259
Synonyms:
(2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 11 | (2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3R,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-triol | 1-DEOXYMANNOJIRIMYCIN | 2-HYDROXYMETHYL-PIPERIDINE-3,4,5-TRIOL | CHEMBL84844 | deoxymannojirimycin
Type:
Small organic molecule
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.1717
SMILES:
OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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