Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50079062
Substrate
n/a
Meas. Tech.
ChEMBL_45424 (CHEMBL657025)
Ki
10±n/a nM
Citation
 Scozzafava, A; Menabuoni, L; Mincione, F; Briganti, F; Mincione, G; Supuran, CT Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring? J Med Chem 42:2641-50 (1999) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50079062
Synonyms:
6-[2-(2-Sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbamoyl]-pyridine-2-carboxylic acid | CHEMBL89163
Type:
Small organic molecule
Emp. Form.:
C16H14N4O7S2
Mol. Mass.:
438.435
SMILES:
NS(=O)(=O)c1nc2ccc(OCCONC(=O)c3cccc(n3)C(O)=O)cc2s1
Structure:
Search PDB for entries with ligand similarity: