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Target
Mast cell protease 9
Ligand
BDBM50098874
Substrate
n/a
Meas. Tech.
ChEMBL_217041 (CHEMBL821575)
Ki
1260±n/a nM
Citation
 Akahoshi, F; Ashimori, A; Sakashita, H; Yoshimura, T; Eda, M; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase. J Med Chem 44:1297-304 (2001) [PubMed]  Article 
Target
Name:
Mast cell protease 9
Synonyms:
MCPT9_MOUSE | MMCP-9 | Mcpt9
Type:
PROTEIN
Mol. Mass.:
26672.66
Organism:
Mus musculus
Description:
ChEMBL_217041
Residue:
246
Sequence:
MQALLFLMALLLPSRAGAEEIIGGVESEPHSRPYMAYVNTFSKKGYVAICGGFLIAPQFVMTAAHCSGRRMTVTLGAHNVRKRECTQQKIKVEKYILPPNYNVSSKFNDIVLLKLKKQANLTSAVDVVPLPGPSDFAKPGTMCWAAGWGRTGVKKSISHTLREVELKIVGEKACKIFRHYKDSLQICVGSSTKVASVYMGDSGGPLLCAGVAHGIVSSGRGNAKPPAIFTRISPHVPWINRVIKGE
  
Inhibitor
Name:
BDBM50098874
Synonyms:
4-{2-[5-Amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-2,2-difluoro-3-oxo-5-phenyl-pentanoic acid benzylamide | CHEMBL24734
Type:
Small organic molecule
Emp. Form.:
C30H26ClF2N5O4
Mol. Mass.:
594.008
SMILES:
Nc1cnc(-c2cccc(Cl)c2)n(CC(=O)NC(Cc2ccccc2)C(=O)C(F)(F)C(=O)NCc2ccccc2)c1=O
Structure:
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