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Target
Cyclin-dependent kinase 2
Ligand
BDBM50133059
Substrate
n/a
Meas. Tech.
ChEMBL_50671 (CHEMBL662526)
IC50
2439±n/a nM
Citation
 Kuo, GH; Prouty, C; DeAngelis, A; Shen, L; O'Neill, DJ; Shah, C; Connolly, PJ; Murray, WV; Conway, BR; Cheung, P; Westover, L; Xu, JZ; Look, RA; Demarest, KT; Emanuel, S; Middleton, SA; Jolliffe, L; Beavers, MP; Chen, X Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors. J Med Chem 46:4021-31 (2003) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50133059
Synonyms:
17,20,23-trioxa-4,12,14,26-tetraazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8,10,12,27,29,31-nonaene-3,5-dione | CHEMBL340935 | Indolylylmaleimide 1
Type:
Small organic molecule
Emp. Form.:
C27H26N4O5
Mol. Mass.:
486.5191
SMILES:
O=C1NC(=O)C2=C1c1cn(CCOCCOCCOCCn3cc2c2cccnc32)c2ccccc12 |c:5|
Structure:
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