Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50176709
Substrate
n/a
Meas. Tech.
ChEMBL_327856 (CHEMBL863986)
Ki
50±n/a nM
Citation
 Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50176709
Synonyms:
(R)-3-(3-methoxyquinuclidin-3-yl)-1,1-dim-tolylprop-2-yn-1-ol | CHEMBL380583
Type:
Small organic molecule
Emp. Form.:
C25H29NO2
Mol. Mass.:
375.5033
SMILES:
CO[C@@]1(CN2CCC1CC2)C#CC(O)(c1cccc(C)c1)c1cccc(C)c1 |wU:2.1,wD:2.11,THB:1:2:5.6:9.8,(-3.03,-42.39,;-1.54,-42.78,;-1.13,-44.27,;-.93,-45.65,;.6,-44.99,;1.97,-45.62,;1.69,-44.23,;.34,-43.62,;.41,-41.99,;.86,-43.09,;-2.63,-44.67,;-4.12,-45.06,;-5.61,-45.46,;-6.01,-43.97,;-7.11,-45.85,;-7.51,-47.34,;-8.99,-47.75,;-10.09,-46.65,;-9.68,-45.16,;-10.77,-44.07,;-8.2,-44.76,;-5.22,-46.95,;-6.31,-48.03,;-5.91,-49.52,;-4.42,-49.92,;-3.33,-48.83,;-1.84,-49.22,;-3.73,-47.35,)|
Structure:
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