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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50176719
Substrate
n/a
Meas. Tech.
ChEMBL_327855 (CHEMBL863985)
Ki
40±n/a nM
Citation
 Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50176719
Synonyms:
4-(3-methoxyquinuclidin-3-yl)-1,2-diphenylbut-3-yn-2-ol | CHEMBL373256
Type:
Small organic molecule
Emp. Form.:
C24H27NO2
Mol. Mass.:
361.4767
SMILES:
COC1(CN2CCC1CC2)C#CC(O)(Cc1ccccc1)c1ccccc1 |THB:1:2:5.6:9.8,(-3.05,-15.66,;-1.56,-16.04,;-1.15,-17.54,;-.96,-18.91,;.58,-18.26,;1.94,-18.89,;1.67,-17.5,;.32,-16.89,;.39,-15.26,;.83,-16.36,;-2.65,-17.93,;-4.14,-18.33,;-5.63,-18.72,;-6.03,-17.24,;-5.24,-20.21,;-3.75,-20.61,;-3.36,-22.1,;-1.88,-22.5,;-.79,-21.42,;-1.19,-19.92,;-2.67,-19.53,;-7.12,-19.12,;-8.22,-18.03,;-9.7,-18.42,;-10.1,-19.91,;-9.01,-21.01,;-7.53,-20.61,)|
Structure:
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