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Target
UDP-glucose 4-epimerase
Ligand
BDBM20625
Substrate
n/a
Meas. Tech.
ChEMBL_424499 (CHEMBL911909)
IC50
75000±n/a nM
Citation
 Urbaniak, MD; Tabudravu, JN; Msaki, A; Matera, KM; Brenk, R; Jaspars, M; Ferguson, MA Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett 16:5744-7 (2006) [PubMed]  Article 
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
GALE | GALE_HUMAN
Type:
PROTEIN
Mol. Mass.:
38282.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_424499
Residue:
348
Sequence:
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
  
Inhibitor
Name:
BDBM20625
Synonyms:
4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | 4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | CHEMBL411 | Diethylstilbestrol | Diethylstilbestrol (1) | Stilbestrol | Stilboestroform
Type:
Small organic molecule
Emp. Form.:
C18H20O2
Mol. Mass.:
268.3502
SMILES:
CC\C(=C(\CC)c1ccc(O)cc1)c1ccc(O)cc1
Structure:
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