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Target
Histone deacetylase 8
Ligand
BDBM50317968
Substrate
n/a
Meas. Tech.
ChEMBL_630915 (CHEMBL1113907)
IC50
20±n/a nM
Citation
 Bressi, JC; de Jong, R; Wu, Y; Jennings, AJ; Brown, JW; O'Connell, S; Tari, LW; Skene, RJ; Vu, P; Navre, M; Cao, X; Gangloff, AR Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity. Bioorg Med Chem Lett 20:3138-41 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50317968
Synonyms:
(R)-N-hydroxy-3-(3-(1-(1-phenylethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | CHEMBL1094792
Type:
Small organic molecule
Emp. Form.:
C24H21N3O2
Mol. Mass.:
383.4424
SMILES:
C[C@H](c1ccccc1)n1c(nc2ccccc12)-c1cccc(\C=C\C(=O)NO)c1 |r|
Structure:
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